SkinCeuticals

The Advanced Defense and Wrinkle Fighting Regimen

    A powerful trio that works together to visibly smooth the appearance of lines, refine texture, and reveal glass skin radiance in just one week.

    The Advanced Defense and Wrinkle Fighting RegimenThe Advanced Defense and Wrinkle Fighting RegimenThe Advanced Defense and Wrinkle Fighting RegimenThe Advanced Defense and Wrinkle Fighting RegimenThe Advanced Defense and Wrinkle Fighting RegimenThe Advanced Defense and Wrinkle Fighting RegimenThe Advanced Defense and Wrinkle Fighting RegimenThe Advanced Defense and Wrinkle Fighting Regimen

    A powerful trio that works together to visibly smooth the appearance of lines, refine texture, and reveal glass skin radiance in just one week.

    SkinCeuticals C E Ferulic main image
    C E Ferulic
    SkinCeuticals P-TIOX main image
    P-TIOX
    P-TIOX Cream variant: Default Title main image
    P-TIOX Wrinkle-Modulating Peptide Cream

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    The Advanced Defense and Wrinkle Fighting Regimen

    $426.80

    Why We Love It

    Reveals glass skin radiance in 1 week of use

    Once absorbed, C E Ferulic remains effective for a minimum of 72 hours

    Visibly reduces deep-set wrinkles and pores

    "I love to recommend C E Ferulic to those looking to prevent skin damage while also targeting signs of aging. This is not only our best-selling vitamin C serum, but it also includes pure vitamin E at 1% which not only neutralizes free radicals but replenishes skin lipids too!"

    Cori Ramos, SkinCeuticals Pro & Licensed Aesthetician

    "P-TIOX is ideal for anyone looking to visibly smooth expression lines and achieve that glass skin look. This advanced peptide serum is inspired by the effects of neurotoxin injections and is clinically proved to improve the appearance of 9 types of wrinkles. I love how lightweight and layerable it is too, it fits easily into any skincare routine."

    Cori Ramos, SkinCeuticals Pro & Licensed Aesthetician

    As we age, expression lines and visible pores become more pronounced. P-TIOX Cream helps visibly smooth lines, refine pores, and improve skin texture over time. I recommend it both as a daily topical solution and to complement in-office injections for both men and women.

    Cori Ramos, SkinCeuticals Pro & Licensed Aesthetician

    Product Information

    Product Information

    Description

    This regimen pairs C E Ferulic, our bestselling antioxidant serum with ferulic acid and vitamins C and E that helps to protect against environmental damage and helps improve visible signs of aging, with the P-TIOX Serum, a peptide formula clinically proven to reduce 9 types of expression lines while refining texture and tone. It finishes with P-TIOX Cream, powered by 10% Myrixin™ and 2% tripeptides to smooth deep lines, minimize the appearance of pores, and deliver non-greasy hydration. Together, this trio delivers glass skin radiance in 1 week and is designed to complement professional neurotoxin injection results.

    UPC:

    Key Benefits

    • C E Ferulic: Provides advanced environmental protection from skin-damaging free radicals caused by sun and pollution. Improves the appearance of fine lines, wrinkles and loss of firmness. Paraben-free and ideal for normal, dry, and sensitive skin types.
    • P-TIOX: Reduces the appearance of 9 types of expression lines, even those neurotoxin injections do not treat. Reveals glass skin radiance in 1 week of use. Hydrates skin up to 24 hours after application. Physician-tested to complement neurotoxin injections. Suitable for all skin types and tones.
    • P-TIOX Cream: Visibly reduces deep-set wrinkles and pores. Smooths skin texture with patent-pending Myrixin™ and advanced peptides. Physician-tested to complement neurotoxin injections. Achieves glass skin appearance when paired with P-TIOX serum. Boosts hydration by +94% in just 1 hour. Suitable for all skin types and tones.
    Q&A

    Q&A

    What color should C E Ferulic be when first opened?
    Upon breaking the plastic and opening, the color of C E Ferulic can vary, ranging from relatively clear to pale yellow to amber. Due to the key ingredients in the formula, the vitamin C serum will begin to darken in color over time. Please note that this does not mean the formula has become ineffective.
    How long does a bottle last after opened?
    It is normal for SkinCeuticals ferulic acid serum for the face to darken after opening due to air and light exposure. The formula will remain effective. It is recommended to be used within 3-6 months after opening with daily application of 4-5 drops to the face, neck, and chest.
    What is the scent/smell of C E Ferulic?
    We do not use preservatives in our products. Since there is no fragrance added to this ferulic acid serum, what you are likely smelling is the natural scent of the vitamins within the formula.
    What are the key differences between P-TIOX Serum and P-TIOX Cream?
    P-TIOX Serum is a concentrated treatment that targets visible expression lines and supports skin smoothness resulting in glass skin radiance with a fluid, transparent formula. P-TIOX Cream complements the serum by addressing pores, deep-set wrinkles, and surface texture while delivering hydration in a fresh cream texture that leaves a non-greasy finish. Used together, they create a complete routine for achieving a glass skin effect.
    Is it better to use anti-wrinkle serums at night or day?
    P-TIOX anti-wrinkle serum should be used twice daily. Apply the peptide serum to a dry face morning and night.
    What age should you start using P-TIOX anti-wrinkle serum?
    Formulas like P-TIOX can be used starting in your 20s. By incorporating an anti-wrinkle peptide serum into your skincare routine early, you can reduce the formation of wrinkles over time and improve the visible appearance of existing contraction lines and wrinkles.
    Do neuro-peptide serums reduce face wrinkles?
    Yes, peptide serums like P-TIOX anti-wrinkle serum visibly reduce face wrinkles. This anti-wrinkle serum is formulated with an advanced peptide complex that combines hexapeptide and dipeptide to reduce the formation and visible appearance of contraction lines and wrinkles. This formula is combined with polyhydroxy acid, niacinamide, and laminaria extract to encourage cell turnover and improve skin texture.
    How does an anti-wrinkle serum work?
    Anti-wrinkle serums work in several ways. P-TIOX contains an advanced peptide complex that is inspired by neurotoxin injection technology to reduce the appearance of wrinkles. This peptide complex works to help reduce the formation and visible appearance of contraction lines and wrinkles.
    How does P-TIOX Cream work?
    P-TIOX Cream uses a patented combination of proprietary Myrixin™ and tripeptide technologies to visibly reduce deep-set wrinkles, refine texture, and help minimize the appearance of enlarged pores. Myrixin™ helps modulate oil activity, while the tripeptide supports structural firmness and surface smoothness. This protective gel cream contains water-bursting micro-droplets that melt into the skin for rapid absorption, delivering instant smoothing and visible texture correction.
    How long does it take for P-TIOX Cream to work?
    Visible improvements, such as reduced pore visibility, can be seen in as little as one month. Continued daily use helps improve the appearance of deep-set wrinkles and refine overall texture. For optimal results, P-TIOX Cream should be used consistently and paired with P-TIOX serum to support the full glass skin routine.
    Can you use P-TIOX Cream under the eyes?
    Yes, you can apply P-TIOX Cream around the eyes. Follow the instructions to apply the cream twice daily to face, neck, and around the eyes. Clinical testing for P-TIOX Cream showed -28% under eye line correction.
    Is P-TIOX Cream suitable for men's skin?
    Yes. P-TIOX Cream is well-suited for men's skin, which often exhibits higher oil production, and more visible pores. This anti-wrinkle cream's patented Myrixin™ and tripeptide technologies help refine texture, reduce pore appearance, and oil production, all common concerns in men's skincare. The lightweight, non-greasy formula melts into the skin, absorbing quickly and supporting smoother, clearer skin without heaviness. This makes it an effective daily moisturizer for men seeking visible improvement in skin clarity and surface refinement.
    Clinical Trials

    Clinical Trials

    Before + After
    • +94%
      increase in hydration in 1 hour*
    • 50%
      reduction in sebum accumulation after 8 hours*
    • -33%
      reduction in wrinkles in 12 weeks**
    • -30%
      reduction in pore visibility in 12 weeks**
    • +20%
      improvement in skin quality in 12 weeks**
    • 20%
      reduction in global fine lines***
    • 36%
      saw a decrease in the appearance of wrinkles****
    • 44.8%
      saw an increase in the appearance of radiance****

    *(P-TIOX Cream) Instrumental test, 31 women, 22-45 y.o.

    **(P-TIOX Cream) Clinical testing of 77 subjects after 12 weeks

    ***(P-TIOX) A 12-week, single center clinical study was conducted on 82 females with Fitzpatrick type I-VI, (52% of subjects with sensitive skin), ages 34-65 and mild to moderate wrinkles, fine lines, pore appearance, rough skin texture evaluated by dermatologist. Efficacy evaluations were conducted at baseline, week 1, week 2, week 4, week 8 and week 12.

    ****(C E Ferulic) Average results shown. 16-week clinical study conducted on 50 caucasian male and female subjects ages 40-60 years old (USA, 2013). For controlled results, subjects used SkinCeuticals Gentle Cleanser and Ultimate UV Defense SPF 30 daily, and Emollience moisturizer as needed.

    Ingredients

    Ingredients

    Vitamin C (C E Ferulic)

    Helps protect against future UVA and UVB sun damage by neutralizing free radicals, minimize the appearance of existing photo-damage, and alleviate skin inflammation.

    Vitamin E (C E Ferulic)

    Helps neutralize free radicals, protect against UV damage, and promote healing.

    Ferulic Acid (C E Ferulic)

    Found naturally in the seeds of some fruits, vegetables, nuts, and grains, it offers anti-aging benefits by combating free radical damage.

    Advanced Peptide Complex - 2% Hexapeptide + 2% Dipeptide (P-TIOX)

    Known to help reduce the appearance of contraction lines.

    5% PHA (P-TIOX)

    A gentle chemical exfoliant to help improve skin texture and enhance skin radiance.

    5% Niacinamide (P-TIOX)

    Strengthens the skin's moisture barrier and reduces the appearance of discoloration.

    10% Myrixin™ (P-TIOX Cream)

    A flavonoid-rich complex inspired by neurotoxin-like effects which targets deep-set wrinkles.

    2% Tripeptide (P-TIOX Cream)

    Designed to help improve the appearance of key contraction lines.

    1% Crystalide Micropeptide (P-TIOX Cream)

    Helps promote skin transparency and radiance.

    See Full Ingredients List See Full Ingredients List

    P-TIOX: Aqua / Water / Eau / Niacinamide / Gluconolactone / Butylene Glycol / Peg/Ppg/Polybutylene Glycol-8/5/3 Glycerin / Alcohol Denat. / Pentylene Glycol / Methyl Gluceth-20 / Glycerin / Potassium Hydroxide / Hydroxyethylcellulose / Salicylic Acid / Chlorphenesin / Phytic Acid / Adenosine / Sodium Benzoate / Laminaria Digitata Extract / Dipeptide Diaminobutyroyl Benzylamide Diacetate / Acetyl Hexapeptide-8

    P-TIOX Wrinkle-Modulating Peptide Cream: aqua / water / eau, butylene glycol, niacinamide, glycerin, dicaprylyl carbonate, pentylene glycol, cetearyl alcohol, 1,2-hexanediol, isododecane, c14-22 alcohols, caprylic/capric triglyceride, vinyl dimethicone, macadamia integrifolia seed oil, glyceryl stearate se, c12-20 alkyl glucoside, nymphaea alba flower extract, acrylates/c10-30 alkyl acrylate crosspolymer, butyrospermum parkii butter / shea butter, c12-16 alcohols, tromethamine, psidium guajava fruit extract, camellia sinensis leaf extract, allium sativum bulb extract / garlic bulb extract, zinc pca, capryloyl salicylic acid, psidium guajava leaf extract, luffa cylindrica fruit extract, hydrogenated lecithin, palmitic acid, cetyl palmitate, ethylhexylglycerin, adenosine, sorbitan stearate, polysorbate 80, tocopherol, ceramide np, dipeptide diaminobutyroyl benzylamide diacetate, sodium benzoate, citric acid, palmitoyl tetrapeptide-10

    C E Ferulic: aqua / water / eau, ethoxydiglycol, ascorbic acid, glycerin, propylene glycol, laureth-23, phenoxyethanol, tocopherol, triethanolamine, ferulic acid, panthenol, sodium hyaluronate.

    How To Use

    How To Use

    • In the morning after cleansing and toning, apply 4 to 5 drops of C E Ferulic to a dry face, neck, and chest before other skincare products.
    • Twice daily,apply 4 to 6 drops of P-TIOX serum to the palm of the hand and dab onto the forehead, cheeks, and chin.
    • Next, dispense a small amount of P-TIOX Cream into clean hands.
    • Gently press cream evenly into skin on face, neck and around the eyes In the morning.
    • Complete your regimen with a SkinCeuticals broad-spectrum sunscreen.
    Shipping & Returns

    Shipping & Returns

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