Best Acne Spot Treatments

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PowerSpot Blemish Lotion main image.
M-61
PowerSpot Blemish Lotion
$16
Exclusive
51
Black Cumin and Cajeput Serum Concentrate main image.
Odacité
Black Cumin and Cajeput Serum Concentrate
$36
17
Deep Acne Liquid Patch main image.
Dermalogica
Deep Acne Liquid Patch
$35
1
Blemish Balm with Plant Based Salicylic Acid main image.
OSEA
Blemish Balm with Plant Based Salicylic Acid
$54
BestSeller
543
Blemish + Age Defense main image.
SkinCeuticals
Blemish + Age Defense
$115
BestSeller
750
Silymarin CF main image.
SkinCeuticals
Silymarin CF
$185
BestSeller
261
Acne Gel With OmniSome main image.
PCA Skin
Acne Gel With OmniSome
$72
101
3 Phase Anti-Blemish Booster Serum main image.
111SKIN
3 Phase Anti-Blemish Booster Serum
$67.5
50
PowerSpot Clear main image.
M-61
PowerSpot Clear
$13
Exclusive
21
LightStim for Acne main image.
LightStim
LightStim for Acne
$169
7
Age Intervention Duality main image.
Jan Marini
Age Intervention Duality
$115
2
Expertly Clear Acne-Treating & Preventing Lotion main image.
Kiehl's Since 1851
Expertly Clear Acne-Treating & Preventing Lotion
$39
1,942
Clearly Corrective Dark Spot Solution main image.
Kiehl's Since 1851
Clearly Corrective Dark Spot Solution
$65
1,685
Clearing Skin Wash main image.
Dermalogica
Clearing Skin Wash
$72
517
Retexturing Activator main image.
SkinCeuticals
Retexturing Activator
$94
BestSeller
316
Retinol 0.5 main image.
SkinCeuticals
Retinol 0.5
$90
BestSeller
267
Retinol 0.3 main image.
SkinCeuticals
Retinol 0.3
$80
BestSeller
153
Epidermal Repair main image.
SkinCeuticals
Epidermal Repair
$90
109
Blemish Control Bar main image.
PCA Skin
Blemish Control Bar
$62
53
Active Serum main image.
IS Clinical
Active Serum
$92
BestSeller
35
Vitablast C Dark Spot Corrector Stick main image.
M-61
Vitablast C Dark Spot Corrector Stick
$92
Exclusive
31
Phyto-Blanc Targeted Dark Spot Corrector main image.
Sisley Paris
Phyto-Blanc Targeted Dark Spot Corrector
$215
8
Absolute Purtiy Toner main image.
Tracie Martyn
Absolute Purtiy Toner
$65
2
Clenziderm M.D. Pore Therapy main image.
Obagi
Clenziderm M.D. Pore Therapy
$49
1

When a pesky blemish tries to steal the spotlight, the best acne spot treatments are your secret weapon for a clearer, more confident complexion. Think of these targeted solutions as your personal beauty troubleshooters—ready to step in and help you face the day with poise. Whether you’re prepping for a big event or simply want to keep your skin looking its best, our curated selection empowers you to tackle breakouts head-on, so you can get back to glowing.

Best Sellers

Dramatically Different Moisturizing Lotion 4.2 oz main image.
Clinique
Dramatically Different Moisturizing Lotion 4.2 oz
$34
9,878
Crème de La Mer Face Cream 2 oz main image.
La Mer
Crème de La Mer Face Cream 2 oz
$390
8,189
Ultra Facial Cream 4.2 oz main image.
Kiehl's Since 1851
Ultra Facial Cream 4.2 oz
$72
8,045
Liquid Facial Soap MILD main image.
Clinique
Liquid Facial Soap MILD
$28
7,623