Best Acne Spot Treatments

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Truly Targeted Acne-Clearing Solution main image.
Kiehl's Since 1851
Truly Targeted Acne-Clearing Solution
$30
4,471
Deep Acne Liquid Patch main image.
Dermalogica
Deep Acne Liquid Patch
$36
1
Black Cumin and Cajeput Serum Concentrate main image.
Odacité
Black Cumin and Cajeput Serum Concentrate
$36
17
Silymarin CF main image.
SkinCeuticals
Silymarin CF
$185
BestSeller
278
Targeted Blemish Treatment main image.
Ogee
Targeted Blemish Treatment
$39
190
Acne Gel With OmniSome main image.
PCA Skin
Acne Gel With OmniSome
$72
102
PowerSpot Pad main image.
M-61
PowerSpot Pad
$70
Exclusive
69
PowerSpot Blemish Lotion main image.
M-61
PowerSpot Blemish Lotion
$20
BestSeller Exclusive
53
LightStim for Acne main image.
LightStim
LightStim for Acne
$169
7
Clearly Corrective Dark Spot Solution main image.
Kiehl's Since 1851
Clearly Corrective Dark Spot Solution
$65
1,797
Acne Solutions Clarifying Lotion main image.
Clinique
Acne Solutions Clarifying Lotion
$22
933
Retinol 0.5 main image.
SkinCeuticals
Retinol 0.5
$90
BestSeller
302
Acne Solutions Acne + Line Correcting Serum main image.
Clinique
Acne Solutions Acne + Line Correcting Serum
$57
215
TheraFace Mask main image.
Therabody
TheraFace Mask
$649.99
BestSeller
182
Retinol 0.3 main image.
SkinCeuticals
Retinol 0.3
$80
BestSeller
172
Epidermal Repair main image.
SkinCeuticals
Epidermal Repair
$90
129
Perfect Peel main image.
M-61
Perfect Peel
$72
BestSeller Exclusive
110
Blemish Control Bar main image.
PCA Skin
Blemish Control Bar
$62
54
Active Serum main image.
IS Clinical
Active Serum
$155
BestSeller
35
Vitablast C Dark Spot Corrector Stick main image.
M-61
Vitablast C Dark Spot Corrector Stick
$92
Exclusive
32
Deeply Purifying Mask With Tropical Resins main image.
Sisley Paris
Deeply Purifying Mask With Tropical Resins
$165
14
Phyto-Blanc Targeted Dark Spot Corrector main image.
Sisley Paris
Phyto-Blanc Targeted Dark Spot Corrector
$225
9
Acne Biotic Moisturizer main image.
Dermalogica
Acne Biotic Moisturizer
$77
1

When a pesky blemish tries to steal the spotlight, the best acne spot treatments are your secret weapon for a clearer, more confident complexion. Think of these targeted solutions as your personal beauty troubleshooters—ready to step in and help you face the day with poise. Whether you’re prepping for a big event or simply want to keep your skin looking its best, our curated selection empowers you to tackle breakouts head-on, so you can get back to glowing.

Best Sellers

Dramatically Different Moisturizing Lotion 4.2 oz main image.
Clinique
Dramatically Different Moisturizing Lotion 4.2 oz
$34
10,281
Dramatically Different Moisturizing Lotion+ main image.
Clinique
Dramatically Different Moisturizing Lotion+
$49
9,835
Ultra Facial Cream 4.2 oz main image.
Kiehl's Since 1851
Ultra Facial Cream 4.2 oz
$72
8,651
Crème de La Mer Face Cream 2 oz main image.
La Mer
Crème de La Mer Face Cream 2 oz
$390
8,383